Common use
Suminat Nasal Spray is a drug that is used for treating migraine attacks with or without the presence of an aura, to relieve cluster headache attacks. Its active component Sumatriptan is a Specific and selective agonist of 5-HT1-serotonin receptors localized mainly in blood vessels of the brain. Migraine headaches are believed to be stipulated by widening of blood vessels in the brain. Sumatriptan causes vasoconstriction of the carotid arterial bed which provides extracranial and intracranial tissues with blood without a significant impact on cerebral blood flow. It also inhibits activity of receptor which are responsible for transmission of pain signals by nerves to the brain.

Dosage and direction
Take Suminat Nasal Spray at the first sign of a migraine headache. Each spray contains 20mg dose of the active substance. One dose of the spray is applied by spraying the medication up one nostril. Second application in two hours after the first one may be approved by your doctor if the symptoms of a migraine persists. Follow all institutions of your doctor. Do not exceed the dose which was recommended to you.

Precautions
Take Suminat Nasal Spray is used only to treat an acute, classic migraine attack or a cluster headache, it should not be used for treatment of certain unusual types of migraine. Patients with uncontrolled high blood pressure should not use Sumatriptan.

Contraindications
Hypersensitivity, basal, ophtalmoplegic, hemiplegic forms of migraine, ischemic heart disease (including suspected it), angina (including angina Printsmetala), myocardial infarction (also in history), hypertension, peripheral arterial occlusive disease, stroke or transient cerebrovascular accident (also in history), liver and kidney failure. Cautiousness should be exercised in patients with epilepsy (including any condition with low epileptic threshold), hypertension, pregnancy, breastfeeding, in infants and adolescents (younger than 18 y.o.), in patients older than 65 y.o.; simultaneous intake of medications which contain ergotamine and its derivatives, MAO inhibitors, and also during the period of 14 days after their cancellation.

Possible side effect
This medication is usually well tolerated and adverse reactions are not expected. Most frequent side effects include nasal irritation, pain or tightness in the chest or throat, tingling, flushing, weakness, dizziness, muscle cramping, diarrhea, abdominal discomfort, sweating, nasal irritation, and injection site reactions. Allergic reactions as adverse reactions of organism to Sumatriptan are also possible.

Drug interaction
Co-administration with ergotamine and medications containing ergotamin may develop a continued spasm of blood vessels (the interval between administration of these medications must be at least 24 h). Interaction of Sumatriptan and MAO inhibitors (isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane)) is also possible resulting in increased concentration of Sumatriptan. Concomitant use of Sumatriptan with selective serotonin reuptake inhibitors or SSRIs, including fluoxetine (Prozac), citalopram (Celexa), paroxetine (Paxil), and sertraline (Zoloft) or serotonin and norepinephrine reuptake inhibitors, including venlafaxine (Effexor), duloxetine (Cymbalta), and desvenlafaxine (Pristiq) may promote weakness, hyperreflexia and poor coordination of movements.

Missed dose
Take Suminat Nasal Spray is not meant for regular use, it is taken only during an attack.

Overdose
Be especially attentive to such symptoms as bluish tinge to the skin, convulsions, dilated pupils, inactivity, lack of coordination, paralysis, redness in the arms and legs, skin changes at the site of injection, slow breathing, sluggishness, tremor as they may be signs of Sumatriptan overdose. Inform your health care advisor immediately about your condition nor seek for emergency medical help.

Storage
Store this medication at a temperature of 2-30 C (36-86 F) in a tight container resistant to light and moisture.

Disclaimer
We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.